News

 

03/10/2018

EU-OPENSCREEN ERIC Inauguration Ceremony

Berlin, 25th September 2018 – The inauguration ceremony of EU-OPENSCREEN ERIC took place at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association in Berlin.

The Czech Republic is represented in EU-OPENSCREEN ERIC by research infrastructure CZ-OPENSCREEN, which is hosted by the Institute of Molecular Genetics, AS CR under the leadership of dr. Petr Bartůněk. Three other specialized partner sites of CZ-OPENSCREEN are Palacky University in Olomouc, Masaryk University in Brno and University of Chemistry and Technology in Prague.

See more details here:

https://www.vyzkumne-infrastruktury.cz/en/2018/09/eu-openscreen-eric-inauguration-ceremony/

https://www.eu-openscreen.eu/newsroom/eu-openscreen-news/ansicht/news/detail/News/festive-eu-openscreen-inauguration-ceremony-on-campus-berlin-buch-45.html

 

30/08/2018

EU-OPENSCREEN ERIC Newsletter - July 2018

Interview with Dr. Petr Bartůněk from Czech-OPENSCREEN in Prague

Portrait of the EU-OPENSCREEN European Chemical Biology Database Site in Prague, Czech Republic

Newsletter July 2018

 

19/04/2018

European Chemical Biology Database finally got its home address

CZ-OPENSCREEN: National Infrastructure for Chemical Biology is a research infrastructure hosted by the Institute of Molecular Genetics, AS CR in Prague. CZ-OPENSCREEN operates the most advanced research infrastructure for basic and applied research in the fields of chemical biology and genetics and provides Open Access to its external users. CZ-OPENSCREEN represents the Czech Republic in the European Research Infrastructure Consortium EU-OPENSCREEN ERIC, whose first constituent assembly was held in Berlin on April 12, 2018.

CZ-OPENSCREEN plays in EU-OPESNCREEN ERIC significant and irreplaceable role. After the demanding evaluation process, the Institute of Molecular Genetics has been chosen as the future European Chemical Biology Database (ECBD) hosting partner site of EU-OPENSCREEN. This great news was announced during the assembly in Berlin mentioned above and the date of April 12, 2018 will always be highlighted in the calendar of this Czech national node.

In ECBD all the data generated by Partner sites of EU-OPENSCREEN consortium will be stored, such as high-throughput screening data or structures of chemical compounds. Data will be accessible to the scientific community upon the open access principles. Before the data go public, they will undergo necessary process of validation and inspection only then will be released to the scientific world. The first validation check will be done by the Partner sites generating the data, then the Prague ECBD team will continue with the detailed validation. User friendly interface will enable a simple search as well as more flexible queries, going beyond the capabilities of a simple search. An advanced search will be available and will enable users to precisely define searched data parameters. The database will also include data analysis tools to help both beginners and advanced users make full use of the data. Besides the common user support, the ECBD website will offer an interactive guide that will introduce the main ECBD user interface features and various data description and visualization options. To increase their accessibility, the fully curated public ECBD data will be subsequently transferred to ChEMBL database. It is important to point out that the CESNET the national e-infrastructure will take care of the hardware, backup strategy and security of ECBD. CESNET generally provides a wide range of data transfer, storage and data processing, it also manages large repository for storing and sharing data. The involvement of CESNET in ECBD project is an excellent example of cooperation of large research infrastructures at national level.  At the end, we can only wish to ECBD team a lot of quality data and wish to scientific community a lot of ideas how to make such data useful for the further research. Infrastructures, in particular, exist to help those scientists who cannot afford the sophisticated technologies and testing to create new data. Their task is to allow these things happen and move the knowledge about our world further, towards new drugs for example.

The infrastructure CZ-OPENSCREEN is currently funded by project provided by the Ministry of Education, Youth and Sports: Large RDI infrastructures projects (2010-2017), identification code: LM2015063

 

19/04/2018

CZ-OPENSCREEN is a founding member of EU-OPENSCREEN

The Czech Republic became the member of the European research Infrastructure Consortium EU-OPENSCREEN ERIC. EU-OPENSCREEN ERIC - the infrastructure for chemical biology was established by the decision of European Commission on March 20, 2018. Its host country is Germany (with the headquarters based in Berlin), and the Czech Republic together with Finland, Latvia, Norway, Poland and Spain belongs to the founder states. The first constituent assembly was in April 12, 2018.

ERIC is a legal framework established by the EU especially for transnational infrastructures to provide them for example a legal capacity recognised in all EU Member States or exemption from VAT.

EU-OPENSCREEN ERIC will offer researchers from Europe and around the world open access to its unique advanced technologies and tools. It will host European Chemical Biology Library of compounds, which will provide to the users mainly for the biological research. EU-OPENSCREEN ERIC will collect and manage all EU-OPENCSREEN generated data and make them publicly accessible. Most of European scientists don’t have access to such advances technologies and compounds collections, which are generally very costly to purchase, operate and maintain. EU-OPENSCREEN consortium will overcome these barriers and financial limitations and it will strengthen the transnational cooperation.

The Czech Republic is represented in EU-OPENSCREEN by research infrastructure CZ-OPENSCREEN, which is hosted by the Institute of Molecular Genetics, AS CR under the leadership of Petr Bartůněk. Three other specialized partner sites of CZ-OPENSCREEN are Palacky University in Olomouc, Masaryk University in Brno and University of Chemistry and Technology in Prague.

CZ-OPENSCREEN: National Infrastructure for Chemical Biology operates the most advanced research infrastructure for basic and applied research in the fields of chemical biology and genetics and provides Open Access to its external users. The main mission of CZ-OPENSCREEN is to identify new molecular probes and to develop new tools for research of chemical compounds, as candidates for the development of new potential therapeutics. CZ-OPENSCREEN is systematically building the library of both commercial chemical compounds as well as originally synthesized in the Czech Republic

The membership of the Czech Republic in EU-OPENSCREEN ERIC is a significant milestone in the existence of CZ-OPENSCREEN and the international appreciation of long term effort to contribute to the identification and development of new drugs.

The infrastructure CZ-OPENSCREEN is currently funded by project provided by the Ministry of Education, Youth and Sports: Large RDI infrastructures projects (2010-2017), identification code: LM2015063

 

 

11/12/2017

The November issue of Chemické listy is dedicated to computational drug design

Would you like to know how to go through the chemical space, how the chemical structures can be presented or how many chemical databases exists? Or you are more interested in the virtual drug design or the storage and management of the HTS data?

More you find in the November issue of Chemické listy, which presents important aspects of computational drug design and the last few articles describe practical computer applications used in chemical-biology from storage and management of chemical compounds to managing of HTS data.

Full text of these articles in the Czech language are available open access. Abstracts are available in English as well.

 

06/11/2017

Open Position

Research associate/ Staff scientist in signal pathways and molecular target profiling

CZ-OPENSCREEN: National Infrastructure of Chemical Biology (Institute of Molecular Genetics, Prague) is seeking a highly-motivated candidate for cellular and biochemical profiling of bioactive compounds and potential drugs.

Job description

  • Development and execution of HTS (high-throughput screening) experiments
  • Coordination of small team of 2-4 scientists/research associates
  • Tissue culture work using standard cancer cell lines and primary cells
  • Assay development for HTS profiling of compound libraries
  • Phenotype-based assays using widefield/confocal microscopy and label-free impedance-based technology
  • Advanced image analysis, data mining, cellular signaling pathways deconvolution, identification of new molecular targets and molecular mechanisms of bioactivity of bioactive compounds

Required skills/qualification:

  • PhD in biochemistry and molecular/cell biology or related biomedical areas
  • Knowledge of cell signaling and biochemical pathways
  • Personal skills such as decision-making, ability to communicate and collaborate with other team members, effective time organization
  • Ability to present and publish the results of scientific work
  • Independence, creativity, flexibility, abstract and critical thinking
  • Excellent verbal and written communication skills in English

Salary and additional information: We offer competitive salary dependent on candidate’s experience. The contract is initially for 1 year with the possible extension up to 5 years.

Unique opportunity to work at state-of-the-art infrastructure in the multidisciplinary team of biochemists, biologists, medicinal chemists and cheminformaticians.

Social benefits:

5 weeks of vacations, sport facilities (squash, volleyball and basketball and fitness) are available at the campus.

Employment type: Full-time contract

Expected starting date: January 2018

How to apply:

The job application should consist of Cover letter and structured CV to be sent to Mrs. Jana Brazinova ( jana.brazinova@img.cas.cz ) by 30 November, 2017.

 

28/07/2017

Probes & Drugs Portal: an interactive, open data resource for chemical biology

Probes & Drugs

logo Nature Methods

Identifying chemical probes that meet all the demands of an experimental design is not a trivial task. Information on candidates are typically scattered over various sources and its gathering can be very time consuming. Even worse in many cases, probe annotations may be already out of date, containing long disproven characteristics leading to their questionable suitability. To simplify the task of identifying high quality chemical tools, the team of scientists at CZ-OPENSCREEN and Institute of Molecular Genetics in Prague led by Petr Bartunek (Director of the National Infrastructure for Chemical Biology) developed the Probes & Drugs (P&D) portal (https://www.probes-drugs.org). P&D portal is a powerful tool for the exploration of bioactive compound space with high attention given to compounds labeled as probes and drugs. It serves as a central hub in chemical biology research offering an intuitive, yet powerful filtering system enhanced by Boolean logic, various visualization tools and an advanced chemical intelligence supported by the integration of several chemical and biological ontologies. Through the combination of these tools, the P&D portal enables to interactively explore the bioactive compound space in a way not achievable before.

Skuta C, Popr M, Muller T, Jindrich J, Kahle M, Sedlak D, Svozil D, Bartunek P. (2017) Probes & Drugs Portal: an interactive, open data resource for chemical biology. Nat Methods 14, 759-760.

http://dx.doi.org/10.1038/nmeth.4365

Full text of Probes & Drugs Portal: an interactive, open data resource for chemical biology

 

05/09/2016

SLAS Translating Research Ideas into Future Therapeutics Conference

The SLAS community organizes the Translating Research Ideas into Future Therapeutics Conference taking place from 29th to 30th of November 2016 in Leuven, Belgium. The conference is designed to engage academic scientists, pharma open innovation groups, infrastructure providers, CROs and funders from across Europe. Thus, the SLAS conference enables the progression through discovery pipelines of novel therapeutic innovations from academia and small companies.

For more information click here.

 

20/10/2015

Updated version of Czech Roadmap of large infrastructures

The Ministry of Education, Youth and Sports has developed an updated version of the Road Map of large infrastructures for research, experimental development and innovation of the Czech Republic for the years 2016 to 2022. The "CZ-OPENSCREEN: National Infrastructure for Chemical Biology" was again included in field of biomedicine.

For more information click here.

 

14/07/2015

EU-OPENSCREEN will be listed in the 2016 ESFRI Roadmap

During ESFRI Plenary Forum on 12th June 2015, ESFRI’s Working Group on Implementation decided that the project EU-OPENSCREEN will be added to the list of active projects in the 2016 ESFRI Roadmap. The updated ESFRI Roadmap 2016 will be made public by the end of 2015.

For more information click here.

 

25/11/2014

Study Bioinformatics

Students have special opportunity to study a Chemical informatics and bioinformatics programme at ICT Prague, guarantees Laboratory of informatics and chemistry.

Bioinformatics is a combination of molecular and cell biology, biochemistry, statistics and computer science. It addresses a development of tools for storage, searching and retrieval of biological data, but its main focus lies on an analysis and interpretation of biological data.

A goal of the study programme "Bioinformatics" is to educate a versatile expert capable of the analysis, processing and interpretation of life science data. Programme graduates will gain a deep knowledge in life sciences, especially in chemistry, molecular biology, mathematics and statistics. Informatics then represents a useful tool helping graduates to look for natural relations in living organisms.

For more information click here.

 

24/9/2013

Ceremonial Opening of the Infrastructure

Figure: Ceremonial opening of CZ-OPENSCREEN infrastructure with (from left to right) Minister of Education, Youth and Sports Dalibor Štys, coordinator of EU-OPENSCREEN Ronald Frank and director of Institute of Molecular Genetics ASCR, v.v.i. Václav Hořejší

 

On Wednesday 24 September 2013, Institute of Molecular Genetics ASCR opened a top scientific centre CZ-OPENSCREEN: National Infrastructure for Chemical Biology. This centre supports basic research in chemical biology and genetics, brings new and excellent conditions for further research development and, moreover, serves as a national node of a pan-european infrastructure ESFRI EU-OPEENSCREEN.

A main goal the CZ-OPENSCREEN is seeking for new therapeutics for cancer, neurodegenerative diseases and diabetes treatment. The centre is equipped with state-of-art technologies operated with distinguished experts in field of chemical biology and genetics. The infrastructure offers potential users Open Access to academic researchers, an access to unique National Compound Collection connected to the European Chemical Biology Database, etc.

The creation of the centre definitely contributes to competitiveness of the Czech Republic confirmed by fact that CZ-OPENSCREEN is one of the priority projects included in The National Roadmap of the Large Infrastructures, as written in Academy Science Bulletin. Learn more.