The November issue of Chemické listy is dedicated to computational drug design

Would you like to know how to go through the chemical space, how the chemical structures can be presented or how many chemical databases exists? Or you are more interested in the virtual drug design or the storage and management of the HTS data?

More you find in the November issue of Chemické listy, which presents important aspects of computational drug design and the last few articles describe practical computer applications used in chemical-biology from storage and management of chemical compounds to managing of HTS data.

Full text of these articles in the Czech language are available open access. Abstracts are available in English as well.



Open Position

Research associate/ Staff scientist in signal pathways and molecular target profiling

CZ-OPENSCREEN: National Infrastructure of Chemical Biology (Institute of Molecular Genetics, Prague) is seeking a highly-motivated candidate for cellular and biochemical profiling of bioactive compounds and potential drugs.

Job description

  • Development and execution of HTS (high-throughput screening) experiments
  • Coordination of small team of 2-4 scientists/research associates
  • Tissue culture work using standard cancer cell lines and primary cells
  • Assay development for HTS profiling of compound libraries
  • Phenotype-based assays using widefield/confocal microscopy and label-free impedance-based technology
  • Advanced image analysis, data mining, cellular signaling pathways deconvolution, identification of new molecular targets and molecular mechanisms of bioactivity of bioactive compounds

Required skills/qualification:

  • PhD in biochemistry and molecular/cell biology or related biomedical areas
  • Knowledge of cell signaling and biochemical pathways
  • Personal skills such as decision-making, ability to communicate and collaborate with other team members, effective time organization
  • Ability to present and publish the results of scientific work
  • Independence, creativity, flexibility, abstract and critical thinking
  • Excellent verbal and written communication skills in English

Salary and additional information: We offer competitive salary dependent on candidate’s experience. The contract is initially for 1 year with the possible extension up to 5 years.

Unique opportunity to work at state-of-the-art infrastructure in the multidisciplinary team of biochemists, biologists, medicinal chemists and cheminformaticians.

Social benefits:

5 weeks of vacations, sport facilities (squash, volleyball and basketball and fitness) are available at the campus.

Employment type: Full-time contract

Expected starting date: January 2018

How to apply:

The job application should consist of Cover letter and structured CV to be sent to Mrs. Jana Brazinova ( ) by 30 November, 2017.



Probes & Drugs Portal: an interactive, open data resource for chemical biology

Probes & Drugs

logo Nature Methods

Identifying chemical probes that meet all the demands of an experimental design is not a trivial task. Information on candidates are typically scattered over various sources and its gathering can be very time consuming. Even worse in many cases, probe annotations may be already out of date, containing long disproven characteristics leading to their questionable suitability. To simplify the task of identifying high quality chemical tools, the team of scientists at CZ-OPENSCREEN and Institute of Molecular Genetics in Prague led by Petr Bartunek (Director of the National Infrastructure for Chemical Biology) developed the Probes & Drugs (P&D) portal ( P&D portal is a powerful tool for the exploration of bioactive compound space with high attention given to compounds labeled as probes and drugs. It serves as a central hub in chemical biology research offering an intuitive, yet powerful filtering system enhanced by Boolean logic, various visualization tools and an advanced chemical intelligence supported by the integration of several chemical and biological ontologies. Through the combination of these tools, the P&D portal enables to interactively explore the bioactive compound space in a way not achievable before.

Skuta C, Popr M, Muller T, Jindrich J, Kahle M, Sedlak D, Svozil D, Bartunek P. (2017) Probes & Drugs Portal: an interactive, open data resource for chemical biology. Nat Methods 14, 759-760.

Full text of Probes & Drugs Portal: an interactive, open data resource for chemical biology



SLAS Translating Research Ideas into Future Therapeutics Conference

The SLAS community organizes the Translating Research Ideas into Future Therapeutics Conference taking place from 29th to 30th of November 2016 in Leuven, Belgium. The conference is designed to engage academic scientists, pharma open innovation groups, infrastructure providers, CROs and funders from across Europe. Thus, the SLAS conference enables the progression through discovery pipelines of novel therapeutic innovations from academia and small companies.

For more information click here.



Updated version of Czech Roadmap of large infrastructures

The Ministry of Education, Youth and Sports has developed an updated version of the Road Map of large infrastructures for research, experimental development and innovation of the Czech Republic for the years 2016 to 2022. The "CZ-OPENSCREEN: National Infrastructure for Chemical Biology" was again included in field of biomedicine.

For more information click here.



EU-OPENSCREEN will be listed in the 2016 ESFRI Roadmap

During ESFRI Plenary Forum on 12th June 2015, ESFRI’s Working Group on Implementation decided that the project EU-OPENSCREEN will be added to the list of active projects in the 2016 ESFRI Roadmap. The updated ESFRI Roadmap 2016 will be made public by the end of 2015.

For more information click here.



Study Bioinformatics

Students have special opportunity to study a Chemical informatics and bioinformatics programme at ICT Prague, guarantees Laboratory of informatics and chemistry.

Bioinformatics is a combination of molecular and cell biology, biochemistry, statistics and computer science. It addresses a development of tools for storage, searching and retrieval of biological data, but its main focus lies on an analysis and interpretation of biological data.

A goal of the study programme "Bioinformatics" is to educate a versatile expert capable of the analysis, processing and interpretation of life science data. Programme graduates will gain a deep knowledge in life sciences, especially in chemistry, molecular biology, mathematics and statistics. Informatics then represents a useful tool helping graduates to look for natural relations in living organisms.

For more information click here.



Ceremonial Opening of the Infrastructure

Figure: Ceremonial opening of CZ-OPENSCREEN infrastructure with (from left to right) Minister of Education, Youth and Sports Dalibor Štys, coordinator of EU-OPENSCREEN Ronald Frank and director of Institute of Molecular Genetics ASCR, v.v.i. Václav Hořejší


On Wednesday 24 September 2013, Institute of Molecular Genetics ASCR opened a top scientific centre CZ-OPENSCREEN: National Infrastructure for Chemical Biology. This centre supports basic research in chemical biology and genetics, brings new and excellent conditions for further research development and, moreover, serves as a national node of a pan-european infrastructure ESFRI EU-OPEENSCREEN.

A main goal the CZ-OPENSCREEN is seeking for new therapeutics for cancer, neurodegenerative diseases and diabetes treatment. The centre is equipped with state-of-art technologies operated with distinguished experts in field of chemical biology and genetics. The infrastructure offers potential users Open Access to academic researchers, an access to unique National Compound Collection connected to the European Chemical Biology Database, etc.

The creation of the centre definitely contributes to competitiveness of the Czech Republic confirmed by fact that CZ-OPENSCREEN is one of the priority projects included in The National Roadmap of the Large Infrastructures, as written in Academy Science Bulletin. Learn more.