KNIME4HTS is a set of new nodes and prepared workflows designed for the processing of HTS data via the Knime Analytics Platform. Using these tools, raw plate data in a matrix or column coordinate format can be analyzed. KNIME4HTS provides functionality for raw data normalization, hit selection, the visualization of plate heatmaps and generation of screening reports. Prepared workflows are also able to visualize large chemical libraries by means of chemical space according to their physico-chemical properties and structural features.
This work was sponsored by grant TA02010212 - ReceptorX: Integrated platform for drug discovery and development by the Technology Agency of the Czech Republic and by the Project NPU I (LO1220) of the Ministry of Education, Youth and Sports.