Chemical libraries (or compound collections/sets) are one of the essential components for research areas of chemical biology and medicinal chemistry. Chemical libraries are collections of small organic compounds, usable in drug discovery and other industrial processes.
For the selection of new compounds, we employ advanced cheminformatic tools. High degree of chemical diversity is one of the fundamental requirements for chemical library used in high throughput screening (HTS). Conversely, we sort and compile the compounds with similar properties (structural, physicochemical, pharmacological, etc.) into smaller, focused sub-libraries also called subsets. By utilizing such specialized subsets, higher economic and time efficiency of the biological activity testing can be achieved.
Our sample collection grows dynamically, and almost every day the sample count is expanding. The highest possible quality of the individual samples in the library is essential for providing reliable and reproducible screening results. Compound integrity in time is assured by optimal storage conditions (-20 °C, nitrogen atmosphere) and gentle handling conditions (limiting freeze-thaw cycles, limited exposure to atmospheric environment, protection of light-sensitive samples from daylight, etc.). Identity of the chemical samples is assured by following strict rules for registration and handling, which contain a series of security checkpoints to prevent unwanted sample confusion.
For more information on Compound management at CZ-OS, please visit section: Equipment/Compound Management
wide coverage of chemical space custom compiled sets of chemicals lead-like and drug-like compounds IP-free
ChemBridge Diverse set
Enamine Diverse set
NCI Diversity II
EU-OS ECBL Diversity set
curated set of tool compounds, chemical probes, and drugs including precompiled commercial libraries from Sigma, Prestwick and Cayman Chemical (prostagnadins and fatty acids)
CZ-OPENSCREEN bioactive set
EU-OPENSCREEN bioactive set
proprietary chemical substances donated by academic/commercial research groups commercially inaccessible chemistry
Academic chemistry collection
Industrial chemistry collection
Natural Products and Extracts